Mouse monoclonal LGR5 antibody [OTI2A2]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Human, African green monkey, Recombinant fragment. Immunogen corresponding to …

LGR5 is differentially expressed in gastrointestinal cancers and that the spatial histoanatomical distribution of LGR5(+) cells has to be considered when their tumour biological significance is sought. LGR5 expression can be related to cellular stemness and can be considered as a new phenotypic marker of residual human corneal limbal stem cells.

LGR5 is the target gene of Wnt signalling. C57BL/6-Lgr5 em1(EGFP-IRES-creERT2-WPRE-polyA)Smoc. Cat. NO. NM-KI-200154. Gene Symbol.

Lgr5

Abstrakt. Absorptiva och sekretoriska celler i tunntarmen härrör från en enda population av Lgr5-uttryckande stamceller. 36, Lgr5, 22.10, 31.03, 41.78, 10.10, 6.64, 8.42, 0.03. 37, Limch1, 5.46, 5.38, 8.18, 1.91, 2.22, 1.56, 0.03.

13 Nov 2019 While Lgr5 deletion at the time of V(D)J recombination resulted in near complete ablation of the B cell lineage in the bone marrow and periphery,

Lgr5. Gene Synonyms. FEX， Gpr49.

These include villus tip telocytes (VTTs) that express Lgr5, a gene previously considered a specific crypt epithelial stem cell marker. VTTs are elongated cells that line the villus tip epithelium and signal through Bmp morphogens and the non-canonical Wnt5a ligand.

The Lgr5 − ISC populations are thought to play Se hela listan på sigmaaldrich.com GPR49 / LGR5 leucine-rich repeat containing G protein-coupled receptor 5. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase Lgr5 + hepatoblasts are at the apex of the hepatoblast hierarchy. (A-F) Embryos expressing either the Lgr5-Cre (Lgr5-IRES-CreERT2) or the ubiquitous Cre (R26R-CreERT2) were induced at E9.5 or E13.5 in order to lineage trace the early hepatoblast pool. Damage activates Lgr5 expression in supporting cells in vitro. We examined utricles from neonatal Lgr5 EGFP-CreERT2/+ mice 1, which report active Wnt signalling and Lgr5 expression in the cochlea We use cookies to enhance the usability of our website.

LGR5 was highly expressed in breast cancer cells. Relative expression of LGR5 was negatively regulated by miR-340. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer. Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2. Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment. Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins.
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Aliases : FEX, HG38, GPR49, GPR67, GRP49. Location: 12q21.1. We investigated the clinical importance of LGR5 in BC and ductal carcinoma in situ (DCIS) to explore LGR5 as a biomarker and a therapeutic target.

· Entity ID: 1 · NIH Common Fund Data 26 Dec 2019 Cycling intestinal Lgr5+ stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells Plasmid HR180-LGR5-iCT from Dr. Toshiro Sato's lab contains the insert iCaspase9-T2A-tdTomato and LGR5 homology arms and is published in Nature.
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Lgr5+ intestinal stem cells are thought to be dispensable for intestinal homeostasis. Using a sensitive Lgr5-2A-DTR model, Tan et al. show that the constant depletion of these Lgr5+ cells in fact compromises intestinal epithelial integrity in vivo and precludes organoid growth in vitro.

Lgr5 + stem cells occur in other epithelia such as the one of the colon, stomach, hair follicles (Alonso and Fuchs, 2003), and mammary glands. LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene.

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LGR5_ENST00000536515, LGR5_ENST00000540815 Sequences You can see various sequences for this gene: cDNA (ENST00000266674.9) Protein (LGR5) Transcript and protein aligned (ENST00000266674.9+LGR5) Gene fusions LGR5 is involved in 1 fusion, with the following gene: NUP107 (1 mutation in 18 samples) Drug sensitivity data Lgr5 is a protein that is important for the maintenance of intestinal homeostasis.